Studying Prostate Cancer in SV-40 Tag Rats
Author Information
Author(s): Harper Curt E, Patel Brijesh B, Cook Leah M, Wang Jun, Shirai Tomoyuki, Eltoum Isam A, Lamartiniere Coral A
Primary Institution: University of Alabama at Birmingham
Hypothesis
The SV-40 Tag rat model can be used to study the development of prostate cancer and the role of sex steroid and growth factor signaling proteins.
Conclusion
The SV-40 Tag rat is a useful model for studying prostate cancer due to its rapid development of precancerous lesions and cancer.
Supporting Evidence
- Prostatic intraepithelial neoplasia developed as early as 2 weeks of age.
- Testosterone and DHT levels were significantly higher in SV-40 Tag rats compared to non-transgenic rats.
- 100% of SV-40 Tag rats developed prostate cancer by 14 weeks of age.
Takeaway
Scientists are using special rats to learn how prostate cancer starts and grows, which can help find better treatments.
Methodology
The study involved histopathological characterization, immunoassays for protein expression, and measurement of hormone levels in SV-40 Tag rats.
Potential Biases
Potential bias in the interpretation of histopathological data due to subjective scoring.
Limitations
The study primarily focuses on a single animal model and may not fully represent human prostate cancer.
Participant Demographics
SV-40 Tag rats, specifically heterozygous males and females.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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