Notch Signaling in Intestinal Stem Cells
Author Information
Author(s): Fre Silvia, Hannezo Edouard, Sale Sanja, Huyghe Mathilde, Lafkas Daniel, Kissel Holger, Louvi Angeliki, Greve Jeffrey, Louvard Daniel, Artavanis-Tsakonas Spyros
Primary Institution: Institut Curie-UMR144 CNRS, Paris, France
Hypothesis
What is the role of Notch signaling in intestinal stem cells?
Conclusion
Notch1 and Notch2 are specifically expressed in intestinal crypt stem cells and are active in maintaining their multipotency.
Supporting Evidence
- Notch1 and Notch2 are specifically expressed in crypt stem cells.
- Notch signaling is active in intestinal stem cells and absorptive progenitors.
- Notch activity is undetectable in secretory and terminally differentiated cells.
Takeaway
This study shows that certain signals help stem cells in the intestine grow and stay healthy, which is important for keeping our gut working well.
Methodology
The study used a series of transgenic mice to analyze Notch receptor expression and activity in intestinal stem cells.
Limitations
The study does not clarify whether the differences in Notch1 and Notch2 expression are due to their relative levels or distinct stem cell populations.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website