Insecticide Resistance in Malaria Vectors in Benin
Author Information
Author(s): Djègbè Innocent, Boussari Olayidé, Sidick Aboubakar, Martin Thibaud, Ranson Hilary, Chandre Fabrice, Akogbéto Martin, Corbel Vincent
Primary Institution: Centre de Recherche Entomologique de Cotonou (CREC)
Hypothesis
What are the dynamics of insecticide resistance in malaria vectors in Benin?
Conclusion
Resistance to pyrethroids and DDT is widespread in malaria vectors in Benin, with both metabolic and target site resistance mechanisms involved.
Supporting Evidence
- High levels of mortality to bendiocarb and fenitrothion were observed.
- Resistance to DDT and pyrethroids was found in both M and S forms of An. gambiae.
- Piperonyl butoxide increased the toxicity of permethrin and restored susceptibility to deltamethrin.
- The L1014S kdr mutation was found for the first time in An. arabiensis in Benin.
- Resistance was not correlated with a change in malaria species or molecular forms.
Takeaway
Mosquitoes that spread malaria in Benin are becoming resistant to the insecticides used to control them, making it harder to fight the disease.
Methodology
Anopheles gambiae populations were collected and tested for insecticide resistance using WHO susceptibility tests and molecular techniques.
Limitations
The study may not cover all geographical variations in insecticide resistance across Benin.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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