Uncoupling Time and Space in the Regulation of Hox Genes
Author Information
Author(s): Tschopp Patrick, Tarchini Basile, Spitz François, Zakany Jozsef, Duboule Denis
Primary Institution: National Research Centre “Frontiers in Genetics”, University of Geneva
Hypothesis
The spatial organization of Hox gene expression does not directly depend on the timing of activation.
Conclusion
The study shows that the mechanisms controlling the timing and spatial distribution of Hox gene expression are distinct and can operate independently.
Supporting Evidence
- Hox genes are clustered in the genome and their positions determine their activation timing.
- Mutant mice with split HoxD clusters showed distinct patterns of gene expression.
- Temporal activation of Hox genes is influenced by their proximity to regulatory elements.
Takeaway
Hox genes help shape how animals develop, and this study found that when they turn on doesn't always affect where they work in the body.
Methodology
The study used mutant alleles at the mouse HoxD locus to analyze regulatory relationships.
Limitations
The study primarily focuses on mouse models, which may not fully represent Hox gene regulation in other species.
Digital Object Identifier (DOI)
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