Glo1 Duplication Linked to Anxiety in Mice
Author Information
Author(s): Williams Richard IV, Lim Jackie E., Harr Bettina, Wing Claudia, Walters Ryan, Distler Margaret G., Teschke Meike, Wu Chunlei, Wiltshire Tim, Su Andrew I., Sokoloff Greta, Tarantino Lisa M., Borevitz Justin O., Palmer Abraham A.
Primary Institution: University of Chicago
Hypothesis
Does a common duplication of the Glo1 gene affect anxiety-like behavior in mice?
Conclusion
The study found that a duplication of the Glo1 gene is associated with increased anxiety-like behavior in mice.
Supporting Evidence
- The presence of the Glo1 duplication was significantly associated with increased anxiety-like behavior in multiple tests.
- Behavioral data from 901 mice showed that those with the duplication spent less time in the center of an open field, indicating higher anxiety.
- Gene expression analysis confirmed that Glo1 expression was higher in mice with the duplication.
Takeaway
Mice with a specific gene duplication tend to be more anxious, which helps scientists understand how genes can affect behavior.
Methodology
The study used Affymetrix exon arrays to detect copy number variants in inbred mouse strains and analyzed their relationship to Glo1 expression and anxiety-like behavior.
Potential Biases
Potential biases may arise from the use of inbred strains, which may not represent the broader genetic diversity found in wild populations.
Limitations
The study's findings may not be generalizable to all populations due to the specific strains used.
Participant Demographics
The study involved various inbred mouse strains and outbred CD-1 mice.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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