Triple Chromosome Translocation in Burkitt's Lymphoma
Author Information
Author(s): Liu Delong, Shimonov Josif, Primanneni Suneeta, Lai Yongrong, Ahmed Tauseef, Seiter Karen
Primary Institution: New York Medical College and Westchester Medical Center
Hypothesis
This study investigates the occurrence of a novel t(8;14;18) triple translocation in patients with Burkitt's lymphoma.
Conclusion
The study identifies a rare triple translocation in two patients with Burkitt's lymphoma, suggesting it may occur more frequently than previously reported.
Supporting Evidence
- The first patient relapsed five and a half years after initial diagnosis but remained chemo-sensitive.
- Gene locus translocations of myc, IgH, and bcl-2 were confirmed by FISH analysis in the second case.
- This is the first report of t(8;14;18) triple translocation associated with clinical cases.
Takeaway
This study found a new type of chromosome change in two people with a serious blood cancer called Burkitt's lymphoma, which might happen more often than we thought.
Methodology
The study involved case reports of two patients with Burkitt's lymphoma, including cytogenetic analysis and treatment outcomes.
Limitations
The study is based on only two cases, which limits the generalizability of the findings.
Participant Demographics
One patient was a 61-year-old Arabic female and the other was a 56-year-old Hispanic male.
Digital Object Identifier (DOI)
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