Anti-malarial Effects of Andrographis paniculata and Hedyotis corymbosa
Author Information
Author(s): Mishra Kirti, Dash Aditya P, Swain Bijay K, Dey Nrisingha
Primary Institution: Institute of Life Sciences, Nalco Square, Bhubaneswar, India
Hypothesis
Can Andrographis paniculata and Hedyotis corymbosa extracts effectively inhibit malaria parasites both in vitro and in vivo?
Conclusion
Both these two plant extracts in combination with curcumin could be an effective, alternative source of herbal anti-malarial drugs.
Supporting Evidence
- The IC50 of Andrographis paniculata was found to be 7.2 μg/ml, while Hedyotis corymbosa had an IC50 of 10.8 μg/ml.
- The combination of the two herbal extracts showed enhanced anti-malarial activity compared to each extract alone.
- In vivo studies showed no toxicity in mice treated with the plant extracts.
Takeaway
This study found that two plants, Andrographis paniculata and Hedyotis corymbosa, can help fight malaria when used together with curcumin.
Methodology
The study tested the anti-malarial activity of plant extracts in vitro on Plasmodium falciparum and in vivo on Balb/c mice infected with Plasmodium berghei.
Limitations
The study primarily focused on in vitro and in vivo models without clinical trials.
Participant Demographics
Balb/c mice were used for in vivo testing.
Digital Object Identifier (DOI)
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