VEGF and Diabetic Retinopathy
Author Information
Author(s): Petrovič Mojca Globočnik, Korošec Peter, Košnik Mitja, Osredkar Joško, Hawlina Marko, Peterlin Borut, Petrovič Daniel
Primary Institution: University Medical Centre Ljubljana
Hypothesis
Is there an association between the –634 C/G polymorphism of the VEGF gene and proliferative diabetic retinopathy (PDR)?
Conclusion
VEGF is an important cytokine in PDR, but the –634 C/G polymorphism does not contribute to genetic susceptibility to PDR.
Supporting Evidence
- Mean serum and vitreous levels of VEGF were significantly higher in PDR compared to controls.
- The –634 C/G VEGF polymorphism was not associated with PDR.
- Higher serum VEGF levels were found in patients with the CC genotype compared to those with CG + GG genotypes.
- Vitreous VEGF levels were significantly higher in diabetic patients with PDR compared to controls.
Takeaway
This study looked at a gene that might affect eye problems in diabetes, but it found that the gene doesn't actually make you more likely to have those problems.
Methodology
Cross-sectional case-control study with 349 Slovene subjects with type 2 diabetes, comparing those with and without PDR.
Limitations
The study only included Slovene subjects, which may limit the generalizability of the findings.
Participant Demographics
349 unrelated Slovene subjects (Caucasians) with type 2 diabetes mellitus, aged 35 to 87 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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