GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells
2011
GP88 Stimulates Growth and Resistance to Letrozole in Breast Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Abrhale Tesfom, Angela Brodie, Gauri Sabnis, Luciana Macedo, Changsheng Tian, Binbin Yue, Ginette Serrero
Primary Institution: University of Maryland School of Medicine
Hypothesis
What role does GP88 play in the acquisition of resistance to letrozole in ER+ breast cancer cells?
Conclusion
GP88 promotes cell growth and resistance to letrozole in breast cancer cells.
Supporting Evidence
- GP88 induced cell proliferation and conferred letrozole resistance in a time- and dose-dependent fashion.
- Letrozole treatment inhibited proliferation, but GP88 blocked this effect.
- Silencing GP88 restored sensitivity to letrozole in resistant cells.
Takeaway
GP88 is a growth factor that helps breast cancer cells grow and resist treatment with letrozole, a common breast cancer drug.
Methodology
The study used aromatase overexpressing breast cancer cell lines to examine the effects of GP88 on cell proliferation and letrozole resistance.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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