17β-Estradiol Inhibits Cell Migration in Colon Cancer Cells
Author Information
Author(s): Hsu Hsi-Hsien, Hu Wei-Syun, Lin Yueh-Min, Kuo Wei-Wen, Chen Li-Mien, Chen Wei-Kung, Hwang Jin-Ming, Tsai Fuu-Jen, Liu Chung-Jung, Huang Chih-Yang
Primary Institution: Mackay Memorial Hospital, Taipei, Taiwan
Hypothesis
Is 17β-estradiol treatment sufficient to inhibit prostaglandin E2-induced cellular motility in human colon cancer cells?
Conclusion
17β-Estradiol treatment significantly inhibits PGE2-induced motility of human LoVo colon cancer cells.
Supporting Evidence
- PGE2 treatment up-regulated uPA and MMP-9 expression via JNK1/2 signaling pathway.
- 17β-Estradiol treatment inhibited PGE2-induced uPA, MMP-9 and cellular motility.
- JNK1/2 signaling pathway mediates PGE2-induced expression of uPA and MMP-9.
Takeaway
This study found that a hormone called 17β-estradiol can stop cancer cells from moving around and spreading by blocking certain signals in the cells.
Methodology
The study analyzed protein expression and cellular motility in PGE2-stimulated human LoVo cells, using various inhibitors and treatments.
Participant Demographics
LoVo colon cancer cell line derived from a 56-year-old male patient.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website