Picornavirus Subversion of the Autophagy Pathway
2011
How Picornaviruses Use Autophagy to Replicate
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Klein Kathryn A., Jackson William T.
Primary Institution: Medical College of Wisconsin
Hypothesis
Picornaviruses subvert the autophagy pathway to promote their own replication.
Conclusion
Picornaviruses exploit the autophagy machinery to create membrane structures that facilitate viral replication.
Supporting Evidence
- Picornaviruses can induce autophagosome-like structures for their replication.
- Different picornaviruses may use distinct mechanisms to hijack the autophagy pathway.
- Studies show that inhibiting autophagy can reduce viral replication in infected cells.
Takeaway
Some viruses trick our cells into using a process called autophagy to help them make more copies of themselves.
Methodology
The review discusses various studies that explore how picornaviruses interact with the autophagy pathway.
Limitations
The specific mechanisms by which different picornaviruses utilize autophagy are not fully understood.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website