The mode of action of dimeticone 4% lotion against head lice, Pediculus capitis
2009
How Dimeticone Lotion Works Against Head Lice
publication
Evidence: moderate
Author Information
Author(s): Burgess Ian F
Primary Institution: Medical Entomology Centre, Insect Research & Development Limited
Hypothesis
The study investigates the mode of action of dimeticone 4% lotion against head lice.
Conclusion
Dimeticone lotion causes head lice to die not from suffocation but from the inability to excrete water, leading to physiological stress and gut rupture.
Supporting Evidence
- Lice treated with dimeticone lotion showed delayed death despite initial immobilization.
- The lotion inhibits water excretion, causing osmotic stress and gut rupture.
- Scanning electron microscopy revealed silicone deposits blocking the spiracles of lice.
Takeaway
This study shows that a lotion used for treating head lice works by blocking their breathing holes, which makes it hard for them to get rid of water, causing them to die.
Methodology
The study involved treating head lice with dimeticone lotion and observing the physiological effects, including weight loss and gut rupture.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website