Paradigm Shift in Treatment of Alzheimer's Disease: Zinc Therapy Now a Conscientious Choice for Care of Individual Patients
2011

Zinc Therapy for Alzheimer's Disease

publication Evidence: moderate

Author Information

Author(s): Tjaard U. Hoogenraad

Primary Institution: University Medical Centre, Utrecht

Hypothesis

Age related free copper toxicosis is a causal factor in pathogenesis of Alzheimer's disease.

Conclusion

Oral zinc therapy is a safe and effective treatment for free copper toxicosis in Alzheimer's disease.

Supporting Evidence

  • Zinc therapy has been shown to improve cognitive functions in some Alzheimer's patients.
  • Free copper levels are elevated in Alzheimer's disease patients, correlating with worse clinical outcomes.
  • Previous studies suggest that zinc can counteract the harmful effects of copper in the body.

Takeaway

This study suggests that giving zinc to people with Alzheimer's might help because too much copper in their bodies can be harmful.

Methodology

The review cumulates evidence from various studies on copper metabolism and zinc therapy in Alzheimer's disease.

Potential Biases

Potential bias in interpreting the effects of zinc therapy due to limited studies.

Limitations

The conclusions about zinc therapy are based on preliminary studies and require further investigation.

Participant Demographics

The study references findings from various populations but does not specify participant demographics.

Digital Object Identifier (DOI)

10.4061/2011/492686

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