Cholinergic Mechanisms in Pain Relief
Author Information
Author(s): Bartolini Alessandro, Cesare Mannelli, Lorenzo Di Ghelardini, Carla
Primary Institution: University of Florence, Department of Preclinical and Clinical Pharmacology
Hypothesis
The role of muscarinic and nicotinic cholinergic receptors in analgesia and neuropathic pain relief is relatively unknown.
Conclusion
Acetyl-L-carnitine can increase acetylcholine synthesis and release, providing both analgesic and anti-neuropathic effects.
Supporting Evidence
- Activation of M1 subtype muscarinic receptors induces analgesia.
- Chronic stimulation of nicotinic receptors has neuronal protective effects.
- Acetyl-L-carnitine increases acetylcholine synthesis and release.
Takeaway
This study talks about how certain drugs can help relieve pain by working with the brain's chemical messengers, especially acetylcholine.
Methodology
The review discusses various pharmacological strategies to enhance acetylcholine synthesis and release.
Limitations
The therapeutic use of direct muscarinic agonists is limited due to severe side effects.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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