Effects of Stopping Bone Medications on Bone Strength
Author Information
Author(s): Shahnazari Mohammad, Yao Wei, Wang Bob, Panganiban Brian, Ritchie Robert O, Hagar Yolanda, Lane Nancy E
Primary Institution: University of California Davis Medical Center
Hypothesis
What are the effects of discontinuing bone-active agents on bone quality and strength?
Conclusion
Alendronate maintained cancellous bone strength, while parathyroid hormone maintained cortical bone strength for four months after treatment withdrawal.
Supporting Evidence
- ALN, PTH, and RAL increased vertebral trabecular bone volume significantly.
- Bone turnover remained suppressed in the ALN group after treatment withdrawal.
- Only PTH treatment maintained cortical bone strength after withdrawal.
Takeaway
This study looked at how stopping certain medications affects bone strength. Some medicines help keep bones strong even after you stop taking them.
Methodology
Ovariectomized rats were treated with different medications for four months, then observed for eight months after treatment withdrawal.
Potential Biases
Potential bias due to the use of a single animal model and specific treatment dosages.
Limitations
The study used a low dose of PTH and only one dose of each medication, limiting comparisons.
Participant Demographics
Six-month-old ovariectomized female Sprague-Dawley rats.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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