Proinflammatory Role of Vascular Endothelial Growth Factor in the Pathogenesis of Rheumatoid Arthritis: Prospects for Therapeutic Intervention
2008
The Role of VEGF in Rheumatoid Arthritis and New Treatment Approaches
publication
Evidence: moderate
Author Information
Author(s): Yoo Seung-Ah, Kwok Seung-Ki, Kim Wan-Uk
Primary Institution: Catholic University of Korea
Hypothesis
VEGF plays a significant role in the pathogenesis of rheumatoid arthritis and targeting it may provide new therapeutic options.
Conclusion
Targeting VEGF may help in managing rheumatoid arthritis by reducing inflammation and synovial hyperplasia.
Supporting Evidence
- VEGF is significantly increased in the synovial fluid of rheumatoid arthritis patients compared to those with osteoarthritis.
- VEGF correlates with disease activity in rheumatoid arthritis, particularly with swollen joint counts.
- Inhibition of VEGF may suppress rheumatoid inflammation and improve treatment outcomes.
Takeaway
VEGF is a bad guy in rheumatoid arthritis because it helps the disease get worse, but we might be able to stop it with new medicines.
Methodology
This review integrates current knowledge of VEGF signaling and discusses potential therapeutic interventions targeting VEGF.
Limitations
The review does not provide new experimental data but synthesizes existing literature.
Digital Object Identifier (DOI)
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