The Rise and Fall of XMRV as a Human Pathogen
Author Information
Author(s): Hohn Oliver, Bannert Norbert
Primary Institution: Center for HIV and Retrovirology, Robert Koch Institute
Hypothesis
Is XMRV a human retrovirus associated with chronic fatigue syndrome?
Conclusion
XMRV is not a clinically relevant infectious human retrovirus and is likely a result of laboratory contamination.
Supporting Evidence
- XMRV was initially thought to be linked to chronic fatigue syndrome but was later found to be absent in patients.
- Multiple studies failed to replicate the original findings linking XMRV to disease.
- Contamination of samples was identified as a likely cause for the initial positive results.
Takeaway
Scientists thought a virus called XMRV might make people sick, but after checking many patients, they found it was just a mistake from the lab.
Methodology
The study involved testing blood samples from CFS patients using PCR, serology, and virus isolation methods.
Potential Biases
Potential contamination of samples and laboratory procedures could lead to false-positive results.
Limitations
The study relies on previously published data and may not account for all variables in patient selection.
Participant Demographics
CFS patients, including those previously reported as XMRV-positive.
Digital Object Identifier (DOI)
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