Gene Expression Related to Lipid Processing in Obesity
Author Information
Author(s): Clemente-Postigo Mercedes, Queipo-Ortuño Maria Isabel, Fernandez-Garcia Diego, Gomez-Huelgas Ricardo, Tinahones Francisco J., Cardona Fernando
Primary Institution: Laboratorio de Investigaciones Biomédicas del Hospital Virgen de la Victoria, Málaga, Spain
Hypothesis
The study aims to analyze the gene expression of factors involved in lipid uptake and processing in adipose tissue according to body mass index (BMI) and the degree of insulin resistance (IR).
Conclusion
Morbidly obese patients have a lower gene expression of factors related to lipid uptake and processing compared to healthy lean individuals.
Supporting Evidence
- LPL and FABP4 gene expression was significantly higher in lean controls compared to morbidly obese patients.
- BMI and plasma insulin levels correlated negatively with LPL and FABP4 expression.
- The study is the first to compare gene expression of lipid processing factors in both visceral and subcutaneous adipose tissue.
Takeaway
This study found that people who are very overweight have a harder time processing fats in their bodies compared to people who are not overweight.
Methodology
Gene expression of factors involved in lipid uptake and processing was measured in visceral and subcutaneous adipose tissue from different groups of patients.
Potential Biases
Potential biases may arise from the selection of participants and the specific conditions under which the study was conducted.
Limitations
The study only included specific groups of patients and may not be generalizable to all populations.
Participant Demographics
The study included 28 morbidly obese patients with high insulin resistance, 10 morbidly obese patients with low insulin resistance, 10 obese patients with low insulin resistance, and 12 lean healthy controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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