Current Therapeutic Options for Alzheimer’s Disease
2007
Current Therapeutic Options for Alzheimer’s Disease
publication
Evidence: moderate
Author Information
Author(s): Alberto Lleó
Primary Institution: Department of Neurology, Hospital Santa Creu i Sant Pau
Conclusion
AChEIs and memantine provide modest symptomatic benefits for cognitive, behavioral, and functional symptoms in Alzheimer's disease.
Supporting Evidence
- AChEIs have been shown to provide small but statistically significant benefits on cognitive and global measures relevant to dementia.
- Memantine has demonstrated better functional and cognitive status in patients compared to placebo.
- Combination therapy of memantine with donepezil showed superior cognitive and functional scores.
Takeaway
Doctors use certain medicines to help people with Alzheimer's feel a little better, but they don't really stop the disease from getting worse.
Methodology
This review discusses current pharmacological options and summarizes clinical evidence supporting their use.
Limitations
The review does not cover nonpharmacologic interventions or long-term benefits of treatments.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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