Case of a Newborn with Down Syndrome and Myeloproliferative Disorder
Author Information
Author(s): Tragiannidis Athanasios, Pana Zoe Dorothea, Papageorgiou Theodotis, Hatzipantelis Emmanuel, Hatzistilianou Maria, Athanassiadou Fani
Primary Institution: Second Pediatric Department, Aristotle University of Thessaloniki, Ahepa General Hospital, Thessaloniki, Greece
Conclusion
This case highlights that tumor lysis syndrome can occur in newborns with transient myeloproliferative disorder and Down syndrome, and it can be effectively treated with rasburicase.
Supporting Evidence
- The patient developed tumor lysis syndrome as a complication of transient myeloproliferative disorder.
- Rasburicase was used successfully to treat the tumor lysis syndrome.
- This is the first reported case of a newborn with Down syndrome and transient myeloproliferative disorder treated with rasburicase.
Takeaway
A baby with Down syndrome had a blood condition that caused too many white blood cells, leading to a serious problem called tumor lysis syndrome, but doctors helped her get better with medicine.
Methodology
The patient was treated with cytosine-arabinoside and rasburicase due to hyperleukocytosis and the risk of tumor lysis syndrome.
Participant Demographics
A seven-day-old Caucasian baby girl with Down syndrome.
Digital Object Identifier (DOI)
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