Smooth Muscle Progenitor Cells in Vascular Disease
Author Information
Author(s): Olivia van Oostrom, Joost O. Fledderus, Dominique de Kleijn, Gerard Pasterkamp, Marianne C. Verhaar
Primary Institution: University Medical Center Utrecht
Hypothesis
Can smooth muscle progenitor cells be considered friends or foes in neointima formation?
Conclusion
Smooth muscle progenitor cells can contribute to both the development of vascular disease and the stabilization of atherosclerotic plaques.
Supporting Evidence
- Smooth muscle progenitor cells can contribute to both neointima formation and plaque stability.
- Different studies show variable contributions of bone marrow-derived cells to vascular diseases.
- Understanding the origins and roles of smooth muscle progenitor cells may lead to new therapies for vascular diseases.
Takeaway
Some special cells in our blood can help fix blood vessels, but sometimes they can also cause problems like blockages.
Methodology
The review discusses various studies on the role of smooth muscle progenitor cells in vascular diseases, including their origins and contributions to neointima formation.
Potential Biases
Conflicting results in studies may arise from differences in methodology and the specific animal models used.
Limitations
The exact role of smooth muscle progenitor cells in vascular disease is not fully understood and may vary based on the type and severity of injury.
Digital Object Identifier (DOI)
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