Gp-340 Variants and Dental Caries Susceptibility
Author Information
Author(s): Anette Jonasson, Christer Eriksson, Howard F. Jenkinson, Carina Källestål, Ingegerd Johansson, Nicklas Strömberg
Primary Institution: Department of Odontology/Cariology, Umeå University, Sweden
Hypothesis
The study examines the association of gp-340 I to III polymorphisms with caries experience and adhesion of S. mutans.
Conclusion
Gp-340 I behaves as a caries susceptibility protein.
Supporting Evidence
- Gp-340 I phenotype correlated positively with caries experience.
- Gp-340 I phenotype showed increased saliva adhesion of S. mutans.
- Purified gp-340 I protein mediated higher adhesion of S. mutans compared to gp-340 II and III.
- Gp-340 I was more common among subjects with the caries susceptibility allele Db.
Takeaway
Some people have a protein called gp-340 that makes them more likely to get cavities because it helps a bad bacteria stick to their teeth.
Methodology
A case-referent study was performed in 12-year-old Swedish children with high or low caries experiences, measuring gp-340 phenotypes and correlating them with caries experience and bacterial adhesion.
Potential Biases
Potential bias due to the selection of participants from specific dental clinics.
Limitations
The study was limited to a small sample size of children from a specific region.
Participant Demographics
12-year-old Swedish children, with 19 high caries cases and 19 low caries referents.
Statistical Information
P-Value
0.027
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website