Advancements in Alternative Splicing Databases
Author Information
Author(s): Pierre de la Grange, Martin Dutertre, Margot Correa, Didier Auboeuf
Primary Institution: INSERM U685/AVENIR, Centre G. Hayem, Hôpital Saint-Louis, Paris, France
Hypothesis
There is a need for interactive databases that provide information about the potential function of each splicing variant and its expression pattern.
Conclusion
The fast DB database provides tools for analyzing the functions of human and mouse gene transcripts and their expression regulation.
Supporting Evidence
- Fast DB provides tools for analyzing the putative functions of transcripts and the regulation of their expression.
- The database integrates information for predicting the functional consequences of alternative splicing.
- Fast DB allows for the prediction of nonsense-mediated mRNA decay and microRNA targeting.
Takeaway
This study created a database that helps scientists understand how different versions of genes work and how they are expressed in different tissues.
Methodology
The study involved compiling human and mouse splicing variants into a database and developing tools for predicting protein isoforms and analyzing transcript expression.
Limitations
The number of ESTs varies among tissues, which may affect the prediction of tissue-specific alternative splicing.
Digital Object Identifier (DOI)
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