Links Between DNA Replication and Translation in Archaea
Author Information
Author(s): Berthon Jonathan, Cortez Diego, Forterre Patrick
Primary Institution: Univ. Paris-Sud 11, CNRS, UMR8621, Institut de Génétique et Microbiologie, France
Hypothesis
The study investigates the genomic context of DNA replication genes in Archaea to infer functional connections between DNA replication and translation.
Conclusion
The analysis suggests a previously unrecognized regulatory network coupling DNA replication and translation in Archaea that may also exist in Eukarya.
Supporting Evidence
- Two distinct sets of DNA replication genes frequently co-localize in archaeal genomes.
- A conserved cluster of genes coding for proteins involved in translation is almost systematically contiguous to genes coding for DNA replication proteins.
- The gene encoding the S27E protein is overexpressed in multiple cancer cell lines.
Takeaway
Scientists looked at the genes involved in DNA copying in certain tiny organisms and found that some of these genes are also linked to the process of making proteins, suggesting they might work together.
Methodology
The study performed a systematic analysis of the genomic environment of all known DNA replication genes in 27 archaeal genomes.
Limitations
The study is limited to the analysis of 27 archaeal genomes and may not represent all archaeal species.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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