Tracking Th17 Cells After Vaccination
Author Information
Author(s): Pötzl Johann, Botteron Catherine, Tausch Eugen, Pedré Xiomara, Mueller André M., Männel Daniela N., Lechner Anja
Primary Institution: Institute of Immunology, University of Regensburg, Regensburg, Germany
Hypothesis
Can CCR6+ Th17 cells be identified and tracked during the immune response after vaccination?
Conclusion
CCR6 is a specific marker for functional antigen-specific Th17 cells during the immune response.
Supporting Evidence
- CCR6+ Th cells produce IL-17 and show signs of activation.
- Vaccination induces antigen-specific CCR6+ Th17 cells.
- Depletion of CCR6+ Th cells prevents severe disease in a mouse model of multiple sclerosis.
Takeaway
The study shows that a specific type of immune cell, called Th17 cells, can be tracked after vaccination, and they play an important role in fighting infections and preventing autoimmune diseases.
Methodology
The study involved analyzing the development and functionality of Th17 cells in immune-competent mice during an immune response to vaccination.
Participant Demographics
Inbred C57BL/6 and SJL/J mice, aged 8-16 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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