Gold nanoparticles induced cloudy swelling to hydropic degeneration, cytoplasmic hyaline vacuolation, polymorphism, binucleation, karyopyknosis, karyolysis, karyorrhexis and necrosis in the liver
2011

Effects of Gold Nanoparticles on Rat Liver

Sample size: 70 publication Evidence: moderate

Author Information

Author(s): Abdelhalim Mohamed Anwar K, Jarrar Bashir M

Primary Institution: King Saud University

Hypothesis

The study investigates the effects of gold nanoparticles on hepatic tissue based on particle size, dose, and exposure duration.

Conclusion

Gold nanoparticles can cause significant liver damage in rats, with effects that are size-dependent and related to the duration of exposure.

Supporting Evidence

  • Gold nanoparticles caused alterations in hepatocytes, including swelling and necrosis.
  • Smaller gold nanoparticles induced more severe liver damage compared to larger ones.
  • The study found that exposure duration affected the severity of liver injury.

Takeaway

Gold nanoparticles can hurt the liver of rats, especially the smaller ones, and the longer they are exposed, the worse it gets.

Methodology

70 healthy male Wistar-Kyoto rats were treated with different sizes and doses of gold nanoparticles for 3 or 7 days, and liver tissues were examined for histological changes.

Limitations

The study primarily focuses on histological changes without exploring long-term effects or mechanisms of toxicity.

Participant Demographics

Healthy male Wistar-Kyoto rats, approximately 12 weeks old, weighing 220-240 grams.

Digital Object Identifier (DOI)

10.1186/1476-511X-10-166

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