Genetic Polymorphisms and Oral Cancer Risk
Author Information
Author(s): L. Varela-Lema, A. Ruano-Ravina, M. A. Juiz Crespo, K. T. Kelsey, L. Loidi, J. M. Barros-Dios
Primary Institution: University of Santiago de Compostela
Hypothesis
The study investigates the relationship between CYP1A1, mEH, and GSTM1 genetic polymorphisms and the risk of oral and pharyngeal cancer.
Conclusion
The results suggest that exon 4 mEH and GSTM1 null polymorphisms might influence oral and pharyngeal cancer risk, but no significant associations were found for the genotypes assessed.
Supporting Evidence
- The study found no significant associations for any of the genotypes assessed.
- 98% of cancer cases were smokers, indicating a strong link between smoking and cancer risk.
- The GSTM1 null genotype was present in 51.1% of cancer patients and 47.7% of controls.
Takeaway
This study looked at how certain genes might affect the risk of getting oral cancer, but it didn't find strong evidence that they do.
Methodology
A case-control study with 92 cancer cases and 130 controls, examining genetic polymorphisms and their interaction with tobacco and alcohol use.
Potential Biases
Potential selection bias due to the hospital-based nature of the study.
Limitations
The small sample size and the hospital-based design may limit the generalizability of the findings.
Participant Demographics
The study included 92 Caucasian male cases and 130 controls, all over 20 years of age.
Statistical Information
Confidence Interval
95%
Digital Object Identifier (DOI)
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