Egr3 Dependent Sympathetic Target Tissue Innervation in the Absence of Neuron Death
2011
Egr3's Role in Sympathetic Target Tissue Innervation
publication
Evidence: moderate
Author Information
Author(s): Li Lin, Eldredge Laurie C., Quach David H., Honasoge Avinash, Gruner Katherine, Tourtellotte Warren G.
Primary Institution: Feinberg School of Medicine, Northwestern University
Hypothesis
The study investigates whether Egr3 is essential for sympathetic target tissue innervation independent of neuron death.
Conclusion
Egr3 is crucial for normal sympathetic target tissue innervation, even when neuron death is prevented.
Supporting Evidence
- Egr3-deficient mice show abnormal sympathetic innervation despite the absence of neuron death.
- Sympathetic innervation to various tissues was significantly reduced in Egr3-deficient mice.
- NGF and NT-3 expression levels were normal in tissues lacking Egr3.
Takeaway
Egr3 helps nerves connect to their target tissues, even if the nerve cells don't die.
Methodology
The study used genetic mouse models to analyze sympathetic innervation in the absence of neuron death.
Limitations
The study does not explore the specific target genes regulated by Egr3.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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