Retroviruses and the Third Synapse
2010
Retroviruses and the Third Synapse
Editorial
Evidence: moderate
Author Information
Author(s): Quentin J. Sattentau
Primary Institution: The University of Oxford
Conclusion
The concept of the virological synapse is important for understanding how viruses spread between cells and may help identify potential targets for intervention.
Supporting Evidence
- HIV-1 can spread between cells more efficiently than through cell-free virions.
- The virological synapse is a structure that allows viruses to transfer between immune cells.
- Cell-to-cell spread of viruses is crucial for understanding their pathogenesis.
Takeaway
Viruses can spread directly from one infected cell to another, which is different from how they usually spread through the air or fluids. This special connection between cells is called a virological synapse.
Limitations
There are still significant gaps in understanding the mechanisms of virological synapses and their role in viral spread.
Digital Object Identifier (DOI)
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