The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage
2011
New Opportunities in Anti-Malaria Drug Discovery
publication
Evidence: moderate
Author Information
Author(s): Emily R. Derbyshire, Maria M. Mota, Jon Clardy
Primary Institution: Harvard Medical School
Hypothesis
Can targeting the liver stage of malaria lead to more effective drug development?
Conclusion
Targeting the liver stage of malaria presents a promising opportunity for developing new anti-malarial drugs.
Supporting Evidence
- Malaria affects 350–500 million people each year.
- Current anti-malarial drugs are becoming less effective due to resistance.
- Targeting the liver stage could prevent malaria infections before they cause symptoms.
Takeaway
Malaria is a serious disease, and finding new medicines that work on the liver stage of the parasite could help stop it from spreading.
Methodology
The article discusses the need for high-throughput screening methods for liver stage malaria parasites.
Limitations
Current drug development primarily focuses on the blood stage, limiting progress in liver stage drug discovery.
Digital Object Identifier (DOI)
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