Comparative Analysis of Neisseria gonorrhoeae Genome Sequences
Author Information
Author(s): Lori A. Snyder, Jeff A. Cole, Mark J. Pallen
Primary Institution: University of Birmingham
Hypothesis
Do differences in the presence and sequence of Correia Repeat Enclosed Elements (CREE) contribute to regulatory differences between Neisseria gonorrhoeae strains?
Conclusion
The study provides strong evidence of the mobility of CREE in Neisseria gonorrhoeae and suggests that these elements contribute to regulatory differences between strains.
Supporting Evidence
- Most CREE locations are conserved between the two strains.
- Some CREE are associated with important genes involved in gonococcal biology.
- Variations in CREE presence may account for differences in strain behavior.
Takeaway
This study looked at two strains of a bacteria called Neisseria gonorrhoeae and found that certain DNA pieces can move around and change how the bacteria behave.
Methodology
Comparative genome analysis of Neisseria gonorrhoeae strains FA1090 and NCCP11945 to identify and analyze Correia Repeat Enclosed Elements (CREE).
Digital Object Identifier (DOI)
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