TRAF6's Role in B Cell Development and Immune Responses
Author Information
Author(s): Kobayashi Takashi, Kim Tae Soo, Jacob Anand, Walsh Matthew C., Kadono Yuho, Fuentes-Pananá Ezequiel, Yoshioka Tomoko, Yoshimura Akihiko, Yamamoto Masahiro, Kaisho Tsuneyasu, Akira Shizuo, Monroe John G., Choi Yongwon
Primary Institution: Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Hypothesis
What is the role of TRAF6 in B cell development and function?
Conclusion
TRAF6 is essential for the development of mature B cells and for effective T cell-dependent and T cell-independent immune responses.
Supporting Evidence
- B cell-specific TRAF6 deficiency leads to reduced mature B cells in the bone marrow and spleen.
- TRAF6-deficient B cells show impaired T cell-dependent antigen responses.
- TRAF6 is critical for the generation of CD5+ B-1 cells.
Takeaway
TRAF6 helps B cells grow and respond to infections, and without it, B cells can't work properly.
Methodology
B cell-specific TRAF6-deficient mice were created to study the role of TRAF6 in B cell development and function.
Limitations
The study primarily focuses on B cell-specific TRAF6 deficiency and may not account for systemic effects.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website