MRI Biomarkers for Alzheimer's Disease
Author Information
Author(s): Lin Ai-Ling, Laird Angela R., Fox Peter T., Gao Jia-Hong
Primary Institution: The University of Texas Health Science Center at San Antonio
Hypothesis
Can multimodal MRI techniques identify biomarkers for Alzheimer's disease in different stages of cognitive impairment?
Conclusion
Multimodal MRI techniques can effectively identify neuroimaging biomarkers that enhance the diagnosis and monitoring of Alzheimer's disease.
Supporting Evidence
- Multimodal MRI can detect brain changes associated with Alzheimer's disease before symptoms appear.
- Structural MRI shows significant brain volume loss in individuals with a family history of Alzheimer's.
- Functional MRI reveals altered brain activity patterns in APOE ε4 carriers, indicating early signs of Alzheimer's.
Takeaway
This study shows that special brain scans can help doctors find signs of Alzheimer's disease early, even before people start having memory problems.
Methodology
The study utilized various MRI techniques to assess structural and functional changes in the brain associated with Alzheimer's disease and cognitive impairment.
Potential Biases
Potential biases may arise from the selection of participants and the interpretation of MRI data.
Limitations
The study may not account for all variables affecting brain health, and results may not be generalizable to all populations.
Participant Demographics
Participants included cognitively normal adults, individuals with mild cognitive impairment, and Alzheimer's disease patients, with a focus on age and genetic factors.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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