Polyamines in Aging and Disease
Author Information
Author(s): Nadège Minois, Didac Carmona-Gutierrez, Frank Madeo
Hypothesis
Polyamines play multiple roles in cell growth, survival, and proliferation, and their levels decline with age, affecting longevity and disease.
Conclusion
Polyamines, particularly spermidine, may have beneficial effects on aging and stress resistance, but their role in diseases, especially cancer, is complex and requires further investigation.
Supporting Evidence
- Polyamines are involved in many functions linked with cell growth, survival, and proliferation.
- Changes in polyamine levels have been associated with aging and diseases.
- Spermidine supplementation has been shown to increase life span in model organisms.
Takeaway
Polyamines are special molecules that help our cells grow and stay healthy, but as we get older, we have less of them, which might make us age faster or get sick.
Methodology
This review summarizes various studies on polyamines, their metabolism, and their roles in aging, stress, and diseases.
Limitations
The review highlights the complexity of polyamines' roles in different contexts, indicating that their effects can vary significantly depending on the specific polyamine and the disease.
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