Distinct Cell Subtypes Within Naïve CD4 T Cells Compartment Shape Its Aging and Senescence
2024
Distinct Cell Subtypes Within Naïve CD4 T Cells and Aging
publication
Author Information
Author(s): Kelly C, Jeon Ashley, Rodriguez Jacob, Prosser Dina, Diegel Morgan, Burnaevskiy Nikolay
Primary Institution: Altius Institute for Biomedical Sciences
Hypothesis
Do individual naïve CD4 T cells differ in expression of aging-associated markers?
Conclusion
Aging in the naïve CD4 compartment is associated with a shifted distribution between more youthful and more senescent cells.
Supporting Evidence
- Naïve CD4 T cells exhibited a less senescent state compared to memory cells.
- Two distinct populations of naïve CD4 T cells were identified based on aging-associated markers.
- The abundance of youthful subpopulations was reduced in older donors’ CD4 populations.
Takeaway
As we get older, the types of cells in our immune system change, with fewer youthful cells and more older, less active cells.
Methodology
High-throughput single-cell RNA-sequencing was used to analyze senescence-associated changes within the CD4 T cell compartment.
Participant Demographics
Multiple donors were used for sequencing total human CD4 T cells.
Digital Object Identifier (DOI)
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