IL-10 Levels and Wheezing in RSV Infected Infants
Author Information
Author(s): Annemieke Schuurhof, Riny Janssen, Hanneke de Groot, Hennie M Hodemaekers, Arja de Klerk, Jan LL Kimpen, Louis Bont
Primary Institution: National Institute for Public Health and the Environment, The Netherlands
Hypothesis
Is there a relationship between IL-10 levels during RSV infection and the development of post-bronchiolitis wheeze in infants?
Conclusion
Higher IL-10 levels during RSV infection are associated with an increased risk of developing post-bronchiolitis wheeze.
Supporting Evidence
- 50% of children develop post-bronchiolitis wheeze after RSV bronchiolitis.
- IL-10 levels were significantly higher in infants who later developed wheeze.
- Follow-up data were available for 185 out of 235 infants.
Takeaway
Infants who have higher levels of a certain protein called IL-10 during a respiratory virus infection are more likely to have wheezing problems later.
Methodology
The study measured IL-10 levels in nasopharyngeal aspirates of infants hospitalized for RSV bronchiolitis and followed up on their wheezing status.
Potential Biases
Potential bias due to the exclusion of infants with pre-existing conditions.
Limitations
The study did not confirm RSV detection by PCR due to limited sample availability.
Participant Demographics
235 previously healthy infants hospitalized for RSV bronchiolitis, with a median age of 2 months.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI 0.57 - 0.98
Statistical Significance
p = 0.02
Digital Object Identifier (DOI)
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