Effects of Tolterodine on Urgency Urinary Incontinence and Quality of Life
Author Information
Author(s): Philip EV Van Kerrebroeck, Con J Kelleher, Karin S Coyne, Zoe Kopp, Marina Brodsky, Joseph T Wang
Primary Institution: Department of Urology, University Hospital Maastricht
Hypothesis
This study determined the correlation of changes in bladder diary variables and other patient-reported outcomes in subjects with overactive bladder treated with tolterodine or placebo.
Conclusion
Improvement in urgency urinary incontinence episodes after treatment was correlated with improvements in patients' perception of bladder-related problems and health-related quality of life.
Supporting Evidence
- Tolterodine ER significantly reduced urgency urinary incontinence episodes compared to placebo.
- 58% of subjects in the tolterodine group reported improvement in bladder condition perception.
- 7 out of 10 health-related quality of life domains improved significantly with tolterodine treatment.
Takeaway
This study found that taking tolterodine helps people with bladder problems feel better and have fewer accidents.
Methodology
Subjects with overactive bladder were treated with 4 mg tolterodine ER or placebo for 12 weeks, completing bladder diaries and questionnaires at baseline and week 12.
Limitations
The analysis is limited to only patients with urgency urinary incontinence, which may not represent all patients with overactive bladder.
Participant Demographics
Most subjects were women (82%) and white (95%), with an average age of around 61 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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