Lipofundin-Induced Hyperlipidemia and Atherosclerosis in Rabbits
Author Information
Author(s): Livan Delgado Roche, Emilio Acosta Medina, Ángela Fraga Pérez, María A. Bécquer Viart, Yosdel Soto López, Viviana Falcón Cama, Ana M. Vázquez López, Gregorio Martínez-Sánchez, Eduardo Fernández-Sánchez
Primary Institution: Center of Studies for Research and Biological Evaluations, University of Havana
Hypothesis
Lipofundin 20% induces hyperlipidemia and oxidative stress, contributing to atherosclerotic lesions in New Zealand white rabbits.
Conclusion
The study found that Lipofundin 20% significantly increases serum lipid levels and promotes oxidative stress, leading to atherosclerotic lesions in rabbits.
Supporting Evidence
- Lipofundin treatment resulted in significantly increased levels of total cholesterol, triglycerides, LDL, and HDL.
- Histopathological analysis showed intimal thickening and lipid accumulation in aortic sections from treated rabbits.
- Oxidative stress markers were significantly elevated in the Lipofundin group compared to controls.
Takeaway
Giving rabbits a fat emulsion called Lipofundin makes their blood fats go up and can cause heart problems.
Methodology
New Zealand rabbits were treated with Lipofundin for 8 days, and various blood and tissue analyses were performed to assess lipid levels and oxidative stress.
Limitations
The study was conducted on a specific animal model, which may not fully represent human atherosclerosis.
Participant Demographics
Standard NZW male rabbits, weighing 2.0–2.5 kg and 12 weeks old.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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