Bromine–lithium exchange for making biaryl ligands
Author Information
Author(s): Bonnafoux Laurence, Leroux Frédéric R, Colobert Françoise
Primary Institution: Laboratoire de stéréochimie, UMR 7509, CNRS-Université de Strasbourg
Hypothesis
Can regioselective bromine–lithium exchange reactions on polybrominated biphenyls enable the construction of new biaryl ligands?
Conclusion
The study demonstrates that regioselective bromine–lithium exchange reactions can effectively construct a new family of di- and monophosphine ligands.
Supporting Evidence
- Regioselective bromine–lithium exchanges allow for the construction of various polysubstituted biphenyls.
- The methodology offers new pathways for synthesizing more sophisticated biaryl scaffolds.
- Mono-, di-, and tetra-substituted ortho-bromobiaryls can be obtained on a gram scale.
Takeaway
This study shows a way to make new types of chemical compounds called biaryl ligands using a special reaction that swaps bromine and lithium atoms.
Methodology
The study utilized regioselective bromine–lithium exchange reactions on polybrominated biphenyls to synthesize various biaryl ligands.
Digital Object Identifier (DOI)
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