Complex interactions of Tyrp1 in the eye
Author Information
Author(s): Lu Hong, Li Liyuan, Watson Edmond R., Williams Robert W., Geisert Eldon E., Jablonski Monica M., Lu Lu
Primary Institution: University of Tennessee Health Science Center
Hypothesis
To use a systems genetics approach to construct and analyze co-expression networks that are causally linked to mutations in a key pigmentation gene, Tyrp1.
Conclusion
The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions, reducing its ability to regulate expression of other genes involved in pigmentation metabolism.
Supporting Evidence
- Mutations in Tyrp1 are associated with oculocutaneous albinism type 3 in humans.
- Gene expression levels were higher in BXD strains with the mutant Tyrp1.
- Significant loss of correlation to traditional genes was observed in strains harboring the mutant Tyrp1.
Takeaway
This study looks at how a gene called Tyrp1 affects eye color and how a mutation in this gene can change how it works with other genes.
Methodology
Gene expression patterns were measured in whole eyes of BXD recombinant inbred mice, and bioinformatics analyses were performed on the expression data.
Limitations
The study primarily focuses on mouse models, which may not fully represent human conditions.
Participant Demographics
292 adult mice of both sexes from various strains.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
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