A Global View of Cancer-Specific Transcript Variants
Author Information
Author(s): He Chunjiang, Zhou Fang, Cheng Zhixiang, Hanhua Zhou, Rongjia Zhou
Primary Institution: Wuhan University
Hypothesis
How does alternative splicing contribute to human tumorigenesis?
Conclusion
The study identifies a significant number of cancer-specific alternative splicing events that could serve as potential diagnostic and therapeutic tools.
Supporting Evidence
- 15,093 cancer-specific variants were identified from 9,989 genes across 27 types of human cancers.
- Approximately 70% of the identified transcripts are novel.
- The study constructed a database (HCSAS) to facilitate access to the identified cancer-specific alternative splicing data.
Takeaway
The study found many new ways that genes can be spliced in cancer, which might help doctors find better ways to diagnose and treat the disease.
Methodology
The study used a subtractive transcriptome-wide analysis to identify cancer-specific alternative splicing events from expressed sequence tags (ESTs) of human cancer and normal tissues.
Limitations
The study may not capture all alternative splicing events due to the reliance on available EST data and potential biases in tissue classification.
Digital Object Identifier (DOI)
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