MicroRNA Regulation and Tissue-Specific Protein Interaction Network
Author Information
Author(s): Zhu Wenliang, Yang Lei, Du Zhimin
Primary Institution: Institute of Clinical Pharmacology, the Second Affiliated Hospital of Harbin Medical University
Hypothesis
How do microRNAs regulate tissue-specific gene expression through protein interaction networks?
Conclusion
MiRNAs that interact with more commonly expressed genes can be expected to play important tissue-specific roles.
Supporting Evidence
- Commonly expressed proteins are under more intensive miRNA control than tissue-specific proteins.
- MiRNAs regulating commonly expressed proteins also affect the expression of more tissue-specific proteins.
- A positive correlation exists between the number of commonly expressed genes targeted by miRNAs and the number of tissue-specific proteins they regulate.
Takeaway
MicroRNAs help control how proteins work in different tissues, and they are especially important for proteins that are commonly found in many tissues.
Methodology
The study constructed tissue-specific protein interaction networks and analyzed miRNA regulation on target genes based on tissue-specific gene expression.
Limitations
The study may have false positive protein interactions and incorrect miRNA targets.
Participant Demographics
The study focused on human tissues, specifically analyzing 10 main types.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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