Diagnosis and Treatment of Candidiasis in Ugandan AIDS Patients
Author Information
Author(s): Maurizio Ravera, Alberto Reggiori, Anna Maria Agliata, Roberto Pidoto Rocco
Primary Institution: Regional Teaching Hospital, Hoima, Uganda
Hypothesis
Can esophageal candidiasis in AIDS patients with oral candidiasis be diagnosed without endoscopy and treated effectively with miconazole?
Conclusion
Miconazole is more effective than nystatin in treating esophageal candidiasis in Ugandan AIDS patients.
Supporting Evidence
- 90.8% of study participants had both oral and esophageal candidiasis.
- Esophageal symptoms were present in 47.1% of patients with esophageal candidiasis.
- Miconazole cured 92.5% of patients with esophageal candidiasis compared to 21.6% for nystatin.
- Oral candidiasis was cured in all patients in both treatment groups.
Takeaway
Doctors can tell if AIDS patients have a throat infection just by looking at their mouth, and a medicine called miconazole works better than nystatin to help them feel better.
Methodology
A randomized cross-over clinical and endoscopic evaluation of 85 Ugandan patients with oral candidiasis.
Limitations
Routine histopathologic assessment was not performed due to cost, and the study was not designed to detect recurrence of candidiasis.
Participant Demographics
85 AIDS patients (45 women, 40 men, mean age 27.1 years).
Statistical Information
P-Value
<0.001
Confidence Interval
69.2 to 92.0
Statistical Significance
p<0.001
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