Using Selective Venous Catheterization to Find Tumors Causing Bone Disease
Author Information
Author(s): Andreopoulou Panagiota, Dumitrescu Claudia E, Kelly Marilyn H, Brillante Beth A, Cutler Peck Carolee M, Wodajo Felasfa M, Chang Richard, Collins Michael T
Primary Institution: National Institute of Dental and Craniofacial Research, National Institutes of Health
Hypothesis
Can selective venous sampling help locate FGF-23-secreting tumors in patients with tumor-induced osteomalacia?
Conclusion
Selective venous sampling is effective in identifying FGF-23-secreting tumors, especially when imaging studies are inconclusive.
Supporting Evidence
- Selective venous sampling helped identify tumors in patients with multiple suspicious lesions.
- The procedure provided additional certainty before complex surgeries.
- FGF-23 levels were measured to confirm the presence of tumors.
- Seven out of fourteen subjects were cured after tumor resection.
Takeaway
Doctors can use a special blood test to find tumors that cause bone problems, helping them treat patients better.
Methodology
The study involved 14 subjects undergoing selective venous sampling to measure FGF-23 levels and identify tumor locations.
Limitations
The procedure was not useful in cases without suspicious lesions on imaging studies.
Participant Demographics
9 males and 5 females, aged 16 to 63 years.
Statistical Information
Confidence Interval
0.47–0.99
Digital Object Identifier (DOI)
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