Nuclear-Targeted Deleted in Liver Cancer 1 (DLC1) Is Less Efficient in Exerting Its Tumor Suppressive Activity Both In Vitro and In Vivo
2011

DLC1's Role in Tumor Suppression and Nuclear Localization

publication 10 minutes Evidence: moderate

Author Information

Author(s): Chan Lo-Kong, Ko Frankie Chi Fat, Sze Karen Man-Fong, Ng Irene Oi-Lin, Yam Judy Wai Ping

Primary Institution: The University of Hong Kong

Hypothesis

The tumor suppressive activity of DLC1 is influenced by its localization in the cell.

Conclusion

Nuclear DLC1 is less effective at suppressing tumor growth compared to its cytoplasmic counterpart.

Supporting Evidence

  • DLC1 shuttles between the cytoplasm and nucleus.
  • Nuclear DLC1 showed reduced ability to suppress colony formation.
  • Nuclear-targeted DLC1 was less effective in inhibiting tumor growth in vivo.

Takeaway

DLC1 is a protein that helps stop cancer, but when it moves to the nucleus of the cell, it doesn't work as well.

Methodology

The study involved creating nuclear-targeted variants of DLC1 and assessing their tumor suppressive activity in vitro and in vivo.

Potential Biases

Potential bias in the selection of cell lines and experimental conditions.

Limitations

The study primarily focused on specific cell lines and may not generalize to all cancer types.

Statistical Information

P-Value

p<0.005

Statistical Significance

p<0.005

Digital Object Identifier (DOI)

10.1371/journal.pone.0025547

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