Hypoxia Affects Oligodendrocyte Development
Author Information
Author(s): Akundi Ravi Shankar, Rivkees Scott A.
Primary Institution: Yale University School of Medicine
Hypothesis
Hypoxia may alter oligodendrocyte cell lineage development contributing to periventricular white matter injury.
Conclusion
Hypoxia interferes with the normal process of oligodendrocyte differentiation by inducing premature maturation of oligodendrocyte precursor cells.
Supporting Evidence
- Hypoxia increased the proportion of myelin basic protein-positive oligodendrocytes.
- Hypoxia led to a decrease in the proportion of platelet-derived growth factor receptor α-positive cells.
- Increased expression of cell cycle regulatory proteins was observed in hypoxic conditions.
Takeaway
When there isn't enough oxygen, brain cells that help with myelination grow up too fast, which might cause problems in the brain.
Methodology
Oligodendrocyte precursor cells were cultured under different oxygen levels to assess the effects of hypoxia on their maturation.
Limitations
The study was conducted in vitro, which may not fully replicate in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website