Making of Viral Replication Organelles by Remodeling Interior Membranes
2010
Making of Viral Replication Organelles by Remodeling Interior Membranes
Commentary
Evidence: moderate
Author Information
Author(s): Sasvari Zsuzsanna, Nagy Peter D.
Primary Institution: Department of Plant Pathology, University of Kentucky
Hypothesis
How do +RNA viruses build viral replication organelles during infection?
Conclusion
The study reveals that +RNA viruses, like poliovirus, create viral replication organelles through dynamic remodeling of host cell membranes.
Supporting Evidence
- Viral replication organelles are formed by the recruitment of host membranes and proteins.
- These organelles are crucial for the replication of +RNA viruses like poliovirus.
- Disruption of the host's secretory pathway aids in viral replication.
Takeaway
Viruses can change the way our cells work to help them make more copies of themselves, creating special structures inside the cells called viral replication organelles.
Limitations
The actual roles of the nonuniform vesicles in PV replication are not yet fully understood.
Digital Object Identifier (DOI)
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