Interaction of tumor cells with the microenvironment
2011

Interaction of Tumor Cells with the Microenvironment

publication Evidence: moderate

Author Information

Author(s): Hendrik Ungefroren, Susanne Sebens, Daniel Seidl, Hendrik Lehnert, Ralf Hass

Primary Institution: University Hospital Schleswig-Holstein

Hypothesis

Understanding the interactions between tumor cells and their microenvironment is essential for comprehending tumor growth and metastasis.

Conclusion

The study highlights the critical role of tumor microenvironment interactions in cancer progression and drug resistance.

Supporting Evidence

  • Tumor cells interact with the extracellular matrix, which affects their ability to migrate and invade.
  • Transforming growth factor-beta (TGF-β) plays a significant role in regulating cancer cell migration and invasion.
  • Tumor-associated macrophages (TAMs) can promote tumor progression and metastasis.

Takeaway

Cancer cells talk to their surroundings, which helps them grow and spread. Understanding this can help us find better treatments.

Methodology

This mini-review discusses recent findings on tumor cell interactions with the extracellular matrix and non-neoplastic cells.

Digital Object Identifier (DOI)

10.1186/1478-811X-9-18

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