Impact of p53 Ser18 and Atm Mutations on Mouse Development and Tumorigenesis
Author Information
Author(s): Heather L. Armata, Punita Shroff, David E. Garlick, Krista Penta, Andrew R. Tapper, Hayla K. Sluss
Primary Institution: University of Massachusetts Medical School
Hypothesis
The study investigates the role of p53Ser18 in tumor suppression independent of ATM.
Conclusion
The loss of p53Ser18 does not significantly affect survival or tumor distribution in Atm-null mice, but it plays a role in embryonic survival.
Supporting Evidence
- Loss of p53Ser18 leads to embryonic lethality in compound mutant mice.
- Atm−/− mice develop tumors predominantly of T-cell origin.
- p53S18A mice develop lymphomas mostly of B-cell origin.
- The presence of p53Ser18 mutation does not significantly alter survival in Atm−/− mice.
Takeaway
Mice with certain genetic mutations related to p53 and Atm can have serious health issues, including not surviving before birth, but the exact effects on tumors can vary.
Methodology
The study involved generating and analyzing various mouse strains with specific genetic mutations to assess their survival, tumor development, and growth characteristics.
Potential Biases
Potential bias in the interpretation of tumor types and survival rates due to genetic variability.
Limitations
The study primarily focuses on specific genetic backgrounds and may not generalize to all populations.
Participant Demographics
Mice were on a mixed 129SvEv/C57Bl6 background.
Statistical Information
P-Value
0.007
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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