Distribution of Sialic Acid Receptors and Influenza A Virus in Infected Pigs
Author Information
Author(s): Trebbien Ramona, Larsen Lars E, Viuff Birgitte M
Primary Institution: Technical University of Denmark
Hypothesis
The study aims to investigate the receptor distribution and predilection sites of avian and swine influenza A viruses in the respiratory tract of pigs.
Conclusion
The study found that the distribution of influenza A virus receptors in pigs is similar to that of humans, with avian influenza preferring to infect alveolar type II epithelial cells.
Supporting Evidence
- Pigs have receptors for both avian and human influenza A viruses.
- The study included 21 pigs, with 8 infected with influenza viruses.
- SA-alpha-2,6 was the predominant receptor in the respiratory tract.
- AIV was found mainly in alveolar type II epithelial cells.
- Receptor expression was diminished in influenza infected areas.
Takeaway
Pigs can get sick from both bird and human flu viruses, and this study looked at where these viruses like to go in the pig's lungs.
Methodology
The study used immunohistochemical methods and specific lectins to investigate receptor distribution in the respiratory tract of pigs.
Limitations
The study may not account for variations in receptor distribution due to factors like age, infection status, or pig breed.
Participant Demographics
Landrace/Yorkshire pigs, two months of age, free from important pathogens.
Digital Object Identifier (DOI)
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